Her next film, the romantic comedy Failure to Launch, co-starring Matthew Mc Conaughey, was released on March 10, 2006, and opened at #1 in the North American box office, grossing slightly over million on its opening weekend, Parker participated in the United States version of the hit U. The executive producer was Lisa Kudrow, and the series featured Parker, husband Matthew Broderick, Kudrow and others.Parker guest starred on season 4 of FOX musical comedy series Glee as Isabelle Wright, a Vogue executive who takes Kurt Hummel under her wing after he graduates and moves to New York.In addition to work in film and television, Parker has gained respect as a stage actor, having appeared in well-reviewed lead roles in the off-Broadway play Sylvia, alongside future husband Matthew Broderick in How to Succeed in Business Without Really Trying, and the Tony Award-nominated Once Upon a Mattress.
The following year, she landed a starring role in the well-received film Honeymoon in Vegas, co-starring Nicolas Cage.
Her role of Sarah Sanderson in Disney's Halloween film Hocus Pocus was a higher grosser at the box office but received negative reviews.
Parker made her Broadway debut at the age of 11 in the 1976 revival of The Innocents, before going on to star in the title role of the Broadway musical Annie in 1979. Story (1991), Honeymoon in Vegas (1992), Hocus Pocus (1993), Ed Wood (1994), The First Wives Club (1996), The Family Stone (2005), Failure to Launch (2006), and Did You Hear About the Morgans? In 2012, Parker returned to television for the first time since Sex and the City, portraying Isabelle Wright in three episodes of the FOX series Glee.
She appeared in the 1984 films Footloose and Firstborn, and returned to Broadway in the 1989 play The Heidi Chronicles. She is currently starring as Frances Dufresne in the HBO series Divorce (2016–present), for which she was nominated for a Golden Globe Award.
She was selected for a role in the new 1977–81 Broadway musical Annie: first in the small role of "July" and then succeeding Andrea Mc Ardle and Shelley Bruce in the lead role of the Depression-era orphan, beginning March 1979. In 1982, Parker was cast as the co-lead of the CBS sitcom Square Pegs.
The show lasted just one season, but Parker's performance, as a shy teen who showed hidden depths, was critically well received.
For this role, she also won four Golden Globe Awards for Best Actress in a Comedy Series and three Screen Actors Guild Awards.
She reprised the role in the films Sex and the City (2008) and Sex and the City 2 (2010).
Also in 1993, she starred as a police diver opposite Bruce Willis in the film Striking Distance.
The following year, she appeared opposite Johnny Depp in the critically acclaimed movie Ed Wood as Wood's girlfriend Dolores Fuller.
The script for an HBO drama/comedy series titled Sex and the City was sent to Parker.